At Basepaws, we continuously strive to enhance the health insights we provide for your pets. We are pleased to announce a new Basepaws product - Breed + Health Dog DNA Test. It includes over 200 genetic-related disorders, analyzed through more than 300 health markers. A genetic marker is a specific change in the gene sequence that is linked to a trait or a disease.
Changes in various genes can be associated with an increased chance of getting certain diseases or having specific traits. Our commitment to offering comprehensive genetic information supports your efforts in proactive pet care.
The full range of genetic disorders featured in the Health Marker section of the Basepaws report is as follows:
Cardiac Disorders
These disorders involve the heart muscle, valves, electrical conduction system, or blood vessels. Symptoms of cardiac disorders may include coughing, difficulty breathing, exercise intolerance, lethargy, fainting, and abdominal distension.
Cardiomyopathy - dilated and other types
Ventricular arrhythmia
Dermatological Disorders
These disorders involve the skin and coat, and can cause skin irritation, hair loss, and abnormal skin growth.
Ichthyosis
Hypotrichosis
Nasal parakeratosis
Endocrine Disorders
These disorders affect the body's hormonal balance and can impact growth and development and various body functions.Â
Dwarfism
Hypothyroidism
Gastrointestinal Disorders
These disorders affect nutrient absorption and the digestive system itself, including the stomach, intestines, liver, and pancreas, causing various digestive problems.
Imerslund-GrÀsbeck syndrome
Familial adenomatous polyposis
Gastrointestinal stromal tumor predisposition
Lundehund syndrome
Hematologic Disorders
These disorders involve medical conditions that affect the blood and may lead to prolonged bleeding and bruising.
Elliptocytosis
Haemophilia (A, B)
Thrombocytopaenia
von Willebrand disease (I, II, III)
Canine Scott Syndrome
Methemoglobinemia
Factor VII deficiency
Factor XI deficiency
Thrombasthenia
Polycythemia
Prekallikrein deficiency
May-Hegglin anomaly
P2Y12 receptor platelet disorder
Ligneous membranitis
Thrombopathia
Immunological Disorders
These disorders impact the immune system and can lead to increased infection risk and immune dysfunction.
C3 deficiency
Leukocyte adhesion deficiency
Severe combined immunodeficiency disease
Leukodystrophy
Trapped neutrophil syndrome
Metabolic Disorders
These disorders are typically associated with the bodyâs inability to break down or correctly process specific substances. In many cases, this is due to a dysfunctional or partially functional enzyme.
Gangliosidosis (GM1, GM2)
Exercise induced metabolic myopathy
Glycogen storage disease
Succinic semialdehyde dehydrogenase deficiency
Mucopolysaccharidosis (III, VI, VII)
Neuronal ceroid lipofuscinosis
Menkes disease
Wilsonâs disease
Ciliary dyskinesia
Hypocatalasia
Beta-mannosidosis
Pyruvate dehydrogenase deficiency
Erythrocytic pyruvate kinase (PK) deficiency
Xanthinuria (I, II)
Musculoskeletal and Connective Tissue Disorders
These disorders affect the muscles, bones, and connective tissues. Common symptoms include muscle weakness, joint problems, and abnormal tissue development.
Osteogenesis imperfecta
Ehlers-Danlos syndrome (dermatosparaxis type, classic type, classic-like type)
Musladin-Lueke syndrome
Hypophosphatasia
Inherited myopathy of Great Danes (IMGD)
Myotonia
Skeletal dysplasia
Ullrich congenital muscular dystrophy (UCMD)
Muscular dystrophy-dystroglycanopathy
Limb-girdle muscular dystrophy (2F, R3)
Other types of muscular dystrophy
Oculoskeletal dysplasia
Australian Labradoodle dystrophinopathy
Exercise-induced collapse syndrome (EIC)
Chondrodysplasia
Spondylocostal dysostosis
Muscular hypertrophy (double muscling)
Myotubular myopathy
Malignant hyperthermia
Inflammatory myopathy
Craniomandibular osteopathy
Neurological Disorders
These disorders involve the nervous system, affecting a dog's brain, spinal cord, and nerves. Such conditions may lead to symptoms ranging from seizures to coordination issues.
Cerebellar ataxia
Spinocerebellar ataxia
Polyneuropathy
Leigh-like subacute necrotizing encephalopathy (SNE)
Mitochondrial neurodegenerative disease with epileptic encephalopathy
Neonatal encephalopathy with seizures
Neurodegenerative vacuolar storage disease
Spongy degeneration with cerebellar ataxia (SDCA)
Congenital myasthenic syndrome
Laryngeal paralysis and polyneuropathy
Leukodystrophy
Generalized myoclonic epilepsy with photosensitivity
Sensory neuropathy
Sensory ataxic neuropathy
Hypomyelination
Krabbe disease
Acral mutilation syndrome
Alexander disease
Bandera's neonatal ataxia (BNAt)
Narcolepsy
L-2-hydroxyglutaricacidemia
Benign familial juvenile epilepsy (BFJE)
Leukoencephalomyelopathy
Neuroaxonal dystrophy
Pelizaeus-Merzbacker disease (shaking pup disease)
Degenerative myelopathy
Juvenile-onset neuroaxonal dystrophy
Dandy-Walker-like malformation (cerebellar hypoplasia)
Multiple system degeneration
Ophthalmologic Disorders
These disorders refer to medical conditions that affect the eyes and vision. Dogs can experience a variety of eye problems, ranging from mild irritations to more serious conditions that may affect their vision or even lead to blindness.
Achromatopsia
Progressive retinal atrophy (multiple types)
Stargardt disease 1
Cone-rod dystrophy (2, 4)
Primary open-angle glaucoma (POAG)
Lens luxation
Multifocal retinopathy (1, 2, 3)
Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis (CKCSID)
Congenital stationary night blindness
Rod-cone dysplasia (1, 3)
Leber congenital amaurosis
Congenital eye malformation
Early retinal degeneration (erd)
Goniodysgenesis and early-onset glaucoma
Renal and Urinary Disorders
These disorders impact kidney function and urinary health. Signs of renal and urinary disorders in dogs may include increased or decreased urination, changes in urine color or consistency, blood in the urine, straining to urinate, increased thirst, weight loss, lethargy, and changes in appetite.
Primary hyperoxaluria, type I (Oxalosis I)
Nephropathy
Nephritis (X-linked)
Renal cystadenocarcinoma and nodular dermatofibrosis
Diffuse cystic renal dysplasia and hepatic fibrosis
Polycystic kidney disease
2,8-DHA urolithiasis (and other types)
Cystinuria (I, II)
Protein-losing nephropathy
Respiratory Disorders
These disorders refer to medical conditions that affect the respiratory system, which includes the nose, throat, trachea (windpipe), lungs, and the muscles involved in breathing.
Recurrent inflammatory pulmonary disease
Respiratory distress syndrome
Pulmonary surfactant metabolism dysfunction
Other Disorders
The Basepaws dog DNA report is constantly updated and includes some other disorders affecting various body systems and functions.Â
Multiple Drug Sensitivity (MDR1)
Amelogenesis imperfecta
Persistent MĂŒllerian duct syndrome
Disorder of sexual development
Dental hypomineralization
Periodic fever syndrome
Non-syndromic hearing loss
Deafness (bilateral, unilateral)
Brachycephaly
Decreased litter size
Exploring Your Dog's Unique Genetic Traits with Basepaws
At Basepaws, we're excited to offer insights into your dog's unique genetic traits through our DNA test. This test uncovers a range of traits from coat colors to physical features. It also explores body size variations and different coat types, including long and curly hair. Understanding these traits helps you connect more with your pet, providing a glimpse into their breed's characteristics and their special features. We test for over 33 trait markers in delivering information on 20 traits from 7 trait categories, which include:
Facial patterns
Melanistic mask
Grizzle
Coat patterns
Dominant yellow/shaded yellow
Wolf-like (sable)
Himalayan
White spotting
Coat colors
Dominant black
Recessive red
Cream
Albinism
Coat modifiers
Dilute
Brown
Coat properties
Shedding
Long hair
Curly hair
Tail
Bob tail
Screw tail
Body size (morphology)
Large
Intermediate
Small
At Basepaws, we're committed to constantly updating our Cat and Dog genetic health and traits markers panels to bring you the latest insights. Our updates are fueled by our in-house research, along with findings from the broader field of feline and canine genetics. Have questions about your petâs report? We're here to help! Just drop us a line at hello@basepaws.com.
