Basepaws Dog Health Report: List of Genetic Conditions and Traits

At Basepaws, we continuously strive to enhance the health insights we provide for your pets. We are pleased to announce a new Basepaws product - Breed + Health Dog DNA Test. It includes over 200 genetic-related disorders, analyzed through more than 300 health markers. A genetic marker is a specific change in the gene sequence that is linked to a trait or a disease.

Changes in various genes can be associated with an increased chance of getting certain diseases or having specific traits. Our commitment to offering comprehensive genetic information supports your efforts in proactive pet care.

The full range of genetic disorders featured in the Health Marker section of the Basepaws report is as follows:

Cardiac Disorders

These disorders involve the heart muscle, valves, electrical conduction system, or blood vessels. Symptoms of cardiac disorders may include coughing, difficulty breathing, exercise intolerance, lethargy, fainting, and abdominal distension.

• Cardiomyopathy - dilated and other types

• Ventricular arrhythmia

Dermatological Disorders

These disorders involve the skin and coat, and can cause skin irritation, hair loss, and abnormal skin growth.

• Ichthyosis

• Hypotrichosis

• Nasal parakeratosis

Endocrine Disorders

These disorders affect the body's hormonal balance and can impact growth and development and various body functions. 

• Dwarfism

• Hypothyroidism

Gastrointestinal Disorders

These disorders affect nutrient absorption and the digestive system itself, including the stomach, intestines, liver, and pancreas, causing various digestive problems.

• Imerslund-Gräsbeck syndrome

• Familial adenomatous polyposis

• Gastrointestinal stromal tumor predisposition

• Lundehund syndrome

Hematologic Disorders

These disorders involve medical conditions that affect the blood and may lead to prolonged bleeding and bruising.

• Elliptocytosis

• Haemophilia (A, B)

• Thrombocytopaenia

• von Willebrand disease (I, II, III)

• Canine Scott Syndrome

• Methemoglobinemia

• Factor VII deficiency

• Factor XI deficiency

• Thrombasthenia

• Polycythemia

• Prekallikrein deficiency

• May-Hegglin anomaly

• P2Y12 receptor platelet disorder

• Ligneous membranitis

• Thrombopathia

Immunological Disorders

These disorders impact the immune system and can lead to increased infection risk and immune dysfunction.

• C3 deficiency

• Leukocyte adhesion deficiency

• Severe combined immunodeficiency disease

• Leukodystrophy

• Trapped neutrophil syndrome

Metabolic Disorders

These disorders are typically associated with the body’s inability to break down or correctly process specific substances. In many cases, this is due to a dysfunctional or partially functional enzyme.

• Gangliosidosis (GM1, GM2)

• Exercise induced metabolic myopathy

• Glycogen storage disease

• Succinic semialdehyde dehydrogenase deficiency

• Mucopolysaccharidosis (III, VI, VII)

• Neuronal ceroid lipofuscinosis

• Menkes disease

• Wilson’s disease

• Ciliary dyskinesia

• Hypocatalasia

• Beta-mannosidosis

• Pyruvate dehydrogenase deficiency

• Erythrocytic pyruvate kinase (PK) deficiency

• Xanthinuria (I, II)

Musculoskeletal and Connective Tissue Disorders

These disorders affect the muscles, bones, and connective tissues. Common symptoms include muscle weakness, joint problems, and abnormal tissue development.

• Osteogenesis imperfecta

• Ehlers-Danlos syndrome (dermatosparaxis type, classic type, classic-like type)

• Musladin-Lueke syndrome

• Hypophosphatasia

• Inherited myopathy of Great Danes (IMGD)

• Myotonia

• Skeletal dysplasia

• Ullrich congenital muscular dystrophy (UCMD)

• Muscular dystrophy-dystroglycanopathy

• Limb-girdle muscular dystrophy (2F, R3)

• Other types of muscular dystrophy

• Oculoskeletal dysplasia

• Australian Labradoodle dystrophinopathy

• Exercise-induced collapse syndrome (EIC)

• Chondrodysplasia

• Spondylocostal dysostosis

• Muscular hypertrophy (double muscling)

• Myotubular myopathy

• Malignant hyperthermia

• Inflammatory myopathy

• Craniomandibular osteopathy

Neurological Disorders

These disorders involve the nervous system, affecting a dog's brain, spinal cord, and nerves. Such conditions may lead to symptoms ranging from seizures to coordination issues.

• Cerebellar ataxia

• Spinocerebellar ataxia

• Polyneuropathy

• Leigh-like subacute necrotizing encephalopathy (SNE)

• Mitochondrial neurodegenerative disease with epileptic encephalopathy

• Neonatal encephalopathy with seizures

• Neurodegenerative vacuolar storage disease

• Spongy degeneration with cerebellar ataxia (SDCA)

• Congenital myasthenic syndrome

• Laryngeal paralysis and polyneuropathy

• Leukodystrophy

• Generalized myoclonic epilepsy with photosensitivity

• Sensory neuropathy

• Sensory ataxic neuropathy

• Hypomyelination

• Krabbe disease

• Acral mutilation syndrome

• Alexander disease

• Bandera's neonatal ataxia (BNAt)

• Narcolepsy

• L-2-hydroxyglutaricacidemia

• Benign familial juvenile epilepsy (BFJE)

• Leukoencephalomyelopathy

• Neuroaxonal dystrophy

• Pelizaeus-Merzbacker disease (shaking pup disease)

• Degenerative myelopathy

• Juvenile-onset neuroaxonal dystrophy

• Dandy-Walker-like malformation (cerebellar hypoplasia)

• Multiple system degeneration

Ophthalmologic Disorders

These disorders refer to medical conditions that affect the eyes and vision. Dogs can experience a variety of eye problems, ranging from mild irritations to more serious conditions that may affect their vision or even lead to blindness.

• Achromatopsia

• Progressive retinal atrophy (multiple types)

• Stargardt disease 1

• Cone-rod dystrophy (2, 4)

• Primary open-angle glaucoma (POAG)

• Lens luxation

• Multifocal retinopathy (1, 2, 3)

• Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis (CKCSID)

• Congenital stationary night blindness

• Rod-cone dysplasia (1, 3)

• Leber congenital amaurosis

• Congenital eye malformation

• Early retinal degeneration (erd)

• Goniodysgenesis and early-onset glaucoma

Renal and Urinary Disorders

These disorders impact kidney function and urinary health. Signs of renal and urinary disorders in dogs may include increased or decreased urination, changes in urine color or consistency, blood in the urine, straining to urinate, increased thirst, weight loss, lethargy, and changes in appetite.

• Primary hyperoxaluria, type I (Oxalosis I)

• Nephropathy

• Nephritis (X-linked)

• Renal cystadenocarcinoma and nodular dermatofibrosis

• Diffuse cystic renal dysplasia and hepatic fibrosis

• Polycystic kidney disease

• 2,8-DHA urolithiasis (and other types)

• Cystinuria (I, II)

• Protein-losing nephropathy

Respiratory Disorders

These disorders refer to medical conditions that affect the respiratory system, which includes the nose, throat, trachea (windpipe), lungs, and the muscles involved in breathing.

• Recurrent inflammatory pulmonary disease

• Respiratory distress syndrome

• Pulmonary surfactant metabolism dysfunction

Other Disorders

The Basepaws dog DNA report is constantly updated and includes some other disorders affecting various body systems and functions. 

• Multiple Drug Sensitivity (MDR1)

• Amelogenesis imperfecta

• Persistent Müllerian duct syndrome

• Disorder of sexual development

• Dental hypomineralization

• Periodic fever syndrome

• Non-syndromic hearing loss

• Deafness (bilateral, unilateral)

• Brachycephaly

• Decreased litter size

Exploring Your Dog's Unique Genetic Traits with Basepaws

At Basepaws, we're excited to offer insights into your dog's unique genetic traits through our DNA test. This test uncovers a range of traits from coat colors to physical features. It also explores body size variations and different coat types, including long and curly hair. Understanding these traits helps you connect more with your pet, providing a glimpse into their breed's characteristics and their special features. We test for over 33 trait markers in delivering information on 20 traits from 7 trait categories, which include:

Facial patterns

• Melanistic mask

• Grizzle

Coat patterns

• Dominant yellow/shaded yellow

• Wolf-like (sable)

• Himalayan

• White spotting

Coat colors

• Dominant black

• Recessive red

• Cream

• Albinism

Coat modifiers

• Dilute

• Brown

Coat properties

• Shedding

• Long hair

• Curly hair

Tail

• Bob tail

• Screw tail

Body size (morphology)

• Large

• Intermediate

• Small

At Basepaws, we're committed to constantly updating our Cat and Dog genetic health and traits markers panels to bring you the latest insights. Our updates are fueled by our in-house research, along with findings from the broader field of feline and canine genetics. Have questions about your pet’s report? We're here to help! Just drop us a line at hello@basepaws.com.