At Basepaws, we continuously strive to enhance the health insights we provide for your pets. We are pleased to announce a new Basepaws product - Breed + Health Dog DNA Test. It includes over 200 genetic-related disorders, analyzed through more than 280 health markers. A genetic marker is a specific change in the gene sequence that is linked to a trait or a disease.
Changes in various genes can be associated with an increased chance of getting certain diseases or having specific traits. Our commitment to offering comprehensive genetic information supports your efforts in proactive pet care.
The full range of genetic disorders featured in the Health Marker section of the Basepaws report is as follows:
These disorders involve the heart muscle, valves, electrical conduction system, or blood vessels. Symptoms of cardiac disorders may include coughing, difficulty breathing, exercise intolerance, lethargy, fainting, and abdominal distension.
Cardiomyopathy - dilated and other types
These disorders involve the skin and coat, and can cause skin irritation, hair loss, and abnormal skin growth.
These disorders affect the body's hormonal balance and can impact growth and development and various body functions.
These disorders affect nutrient absorption and the digestive system itself, including the stomach, intestines, liver, and pancreas, causing various digestive problems.
Familial adenomatous polyposis
Gastrointestinal stromal tumor predisposition
These disorders involve medical conditions that affect the blood and may lead to prolonged bleeding and bruising.
Haemophilia (A, B)
von Willebrand disease (I, II, III)
Canine Scott Syndrome
Factor VII deficiency
Factor XI deficiency
P2Y12 receptor platelet disorder
These disorders impact the immune system and can lead to increased infection risk and immune dysfunction.
Leukocyte adhesion deficiency
Severe combined immunodeficiency disease
Trapped neutrophil syndrome
These disorders are typically associated with the body’s inability to break down or correctly process specific substances. In many cases, this is due to a dysfunctional or partially functional enzyme.
Gangliosidosis (GM1, GM2)
Exercise induced metabolic myopathy
Glycogen storage disease
Succinic semialdehyde dehydrogenase deficiency
Mucopolysaccharidosis (III, VI, VII)
Neuronal ceroid lipofuscinosis
Pyruvate dehydrogenase deficiency
Erythrocytic pyruvate kinase (PK) deficiency
Xanthinuria (I, II)
Musculoskeletal and Connective Tissue Disorders
These disorders affect the muscles, bones, and connective tissues. Common symptoms include muscle weakness, joint problems, and abnormal tissue development.
Ehlers-Danlos syndrome (dermatosparaxis type, classic type, classic-like type)
Inherited myopathy of Great Danes (IMGD)
Ullrich congenital muscular dystrophy (UCMD)
Limb-girdle muscular dystrophy (2F, R3)
Other types of muscular dystrophy
Australian Labradoodle dystrophinopathy
Exercise-induced collapse syndrome (EIC)
Muscular hypertrophy (double muscling)
These disorders involve the nervous system, affecting a dog's brain, spinal cord, and nerves. Such conditions may lead to symptoms ranging from seizures to coordination issues.
Leigh-like subacute necrotizing encephalopathy (SNE)
Mitochondrial neurodegenerative disease with epileptic encephalopathy
Neonatal encephalopathy with seizures
Neurodegenerative vacuolar storage disease
Spongy degeneration with cerebellar ataxia (SDCA)
Congenital myasthenic syndrome
Laryngeal paralysis and polyneuropathy
Generalized myoclonic epilepsy with photosensitivity
Sensory ataxic neuropathy
Acral mutilation syndrome
Bandera's neonatal ataxia (BNAt)
Benign familial juvenile epilepsy (BFJE)
Pelizaeus-Merzbacker disease (shaking pup disease)
Juvenile-onset neuroaxonal dystrophy
Dandy-Walker-like malformation (cerebellar hypoplasia)
Multiple system degeneration
These disorders refer to medical conditions that affect the eyes and vision. Dogs can experience a variety of eye problems, ranging from mild irritations to more serious conditions that may affect their vision or even lead to blindness.
Progressive retinal atrophy (multiple types)
Stargardt disease 1
Cone-rod dystrophy (2, 4)
Primary open-angle glaucoma (POAG)
Multifocal retinopathy (1, 2, 3)
Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis (CKCSID)
Congenital stationary night blindness
Rod-cone dysplasia (1, 3)
Leber congenital amaurosis
Congenital eye malformation
Early retinal degeneration (erd)
Goniodysgenesis and early-onset glaucoma
Renal and Urinary Disorders
These disorders impact kidney function and urinary health. Signs of renal and urinary disorders in dogs may include increased or decreased urination, changes in urine color or consistency, blood in the urine, straining to urinate, increased thirst, weight loss, lethargy, and changes in appetite.
Primary hyperoxaluria, type I (Oxalosis I)
Renal cystadenocarcinoma and nodular dermatofibrosis
Diffuse cystic renal dysplasia and hepatic fibrosis
Polycystic kidney disease
2,8-DHA urolithiasis (and other types)
Cystinuria (I, II)
These disorders refer to medical conditions that affect the respiratory system, which includes the nose, throat, trachea (windpipe), lungs, and the muscles involved in breathing.
Recurrent inflammatory pulmonary disease
Respiratory distress syndrome
Pulmonary surfactant metabolism dysfunction
The Basepaws dog DNA report is constantly updated and includes some other disorders affecting various body systems and functions.
Multiple Drug Sensitivity (MDR1)
Persistent Müllerian duct syndrome
Disorder of sexual development
Periodic fever syndrome
Non-syndromic hearing loss
Deafness (bilateral, unilateral)
Decreased litter size
Exploring Your Dog's Unique Genetic Traits with Basepaws
At Basepaws, we're excited to offer insights into your dog's unique genetic traits through our DNA test. This test uncovers a range of traits from coat colors to physical features. It also explores body size variations and different coat types, including long and curly hair. Understanding these traits helps you connect more with your pet, providing a glimpse into their breed's characteristics and their special features. We test for over 33 trait markers in delivering information on 20 traits from 7 trait categories, which include:
Dominant yellow/shaded yellow
Body size (morphology)
At Basepaws, we're committed to constantly updating our Cat and Dog genetic health and traits markers panels to bring you the latest insights. Our updates are fueled by our in-house research, along with findings from the broader field of feline and canine genetics. Have questions about your pet’s report? We're here to help! Just drop us a line at firstname.lastname@example.org.