Disease overview

Factor XII deficiency, also known as Hageman deficiency, is a relatively common disorder resulting in improper blood coagulation. The disease seems to be more prevalent in cats from the Midwestern United States. The condition has minimal impact on quality of life but needs to be considered if any surgical intervention is planned.

Gene name

F12

Inheritance

Autosomal recessive

Signs and symptoms

In many cases, cats are asymptomatic with this disease alone. However, when combined with Haemophilia A, excessive bleeding is seen with physical trauma or surgery. In some cases, Factor XII deficiency alone can elongate the activated partial thromboplastin time (aPTT).

How is it diagnosed

Diagnosis of this condition is done via a genetic test. However, in most cases, it will not be diagnosed unless it is combined with another clotting disorder that presents with clinical signs.

Breeds at higher risk

Current data does not indicate that specific breeds are at a higher risk

Citations

https://pubmed.ncbi.nlm.nih.gov/24793828/ https://pubmed.ncbi.nlm.nih.gov/31022435/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.