Disease overview

Autoimmune lymphoproliferative syndrome (ALPS) is an autosomal recessive disease that causes substantial enlargement of the lymph nodes and spleen due to accumulation of lymphocytes. This phenomenon is caused by the disrupted normal apoptosis (cell death) of lymphocytes. The condition is lethal.

Gene name

FASLG

Inheritance

Autosomal recessive

Signs and symptoms

The most common clinical sign of ALPS is the enlargement of the lymph nodes and the spleen. Some kittens will also show regenerative hemolytic anemia, abdominal distension, lethargy, and weight loss. Kittens will typically die or require euthanasia around 2-4 months of age, depending on the disease progression.

How is it diagnosed

Diagnosis of this disease requires lymph node cytology and immunohistochemistry. A genetic test is sometimes used to confirm disease or carrier status.

Breeds at higher risk

Citations

https://pubmed.ncbi.nlm.nih.gov/28814155/ https://pubmed.ncbi.nlm.nih.gov/27770190/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.