Disease overview

Pyruvate kinase deficiency of erythrocytes is an inherited metabolic disorder characterized by disrupted survival or red blood cells (erythrocytes). Cats suffering from the disease develop anemia. The anemia is intermittent, with variable age of onset.

Gene name

PKLR

Inheritance

Autosomal recessive

Signs and symptoms

This disease often manifests as lethargy, diarrhea, decreased appetite, pale mucous membranes, weight loss, icterus, poor coat quality, and splenomegaly. If left untreated, most cats will require euthanasia by 5 years of age.

How is it diagnosed

Diagnosis of this condition is done via analysis of a blood sample. Genetic testing is also used for a definitive diagnosis of affected cats.

Breeds at higher risk

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Citations

https://pubmed.ncbi.nlm.nih.gov/19178476/ https://pubmed.ncbi.nlm.nih.gov/23110753/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.