Disease overview

Alpha-mannosidosis is a lysosomal storage disorder characterized by the deficiency of the alpha-D-mannosidase enzyme. A defective enzyme causes progressive accumulation of mannose-rich oligosaccharides in all tissues, which disrupts cellular functions and causes cell death.

Gene name

MAN2B

Inheritance

Autosomal recessive

Signs and symptoms

Cats with this disorder often have ataxia, tremors, slowed growth, corneal abnormalities, hepatomegaly, and changes to their skull. Cats can also display abnormal behavior. In Persians, this disease is also associated with neonatal death and stillbirths.

How is it diagnosed

Diagnosis of alpha mannosidosis involves the detection of alpha-mannosidase enzyme activity in peripheral blood leukocytes, or white blood cells.

Breeds at higher risk

Citations

https://pubmed.ncbi.nlm.nih.gov/9396732/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.