Dihydropyrimidinuria

Disease overview

Dihydropyrimidiuria is a relatively rare metabolic syndrome that occurs due to an enzyme (dihydropyrimidinase) deficiency in the pyrimidine degradation pathway.

Gene name

DPYS

Inheritance

Likely autosomal recessive

Signs and symptoms

Clinical signs seen in cats with this disease can include lethargy, weight loss or a consistently low body condition score, vomiting dihydropyrimidine in the urine, and high ammonia levels in the blood.

How is it diagnosed

Diagnosis of this disease is made based on clinical signs and a genetic test for the mutation.

Breeds at higher risk

Current data does not indicate that specific breeds are at a higher risk.

Citations

https://pubmed.ncbi.nlm.nih.gov/23430934/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.