Disease overview

Late-onset photoreceptor degeneration, also known as retinal degeneration II is a progressive retinal atrophy (PRA) with an autosomal recessive mode of inheritance. The disease is marked by the deterioration of the retina caused by the progressive death of retinal cells. This particular form of feline PRA is considered to be a model for human retinitis pigmentosa, which is characterized by night blindness, loss of peripheral vision and subsequent loss of central vision.

Gene name

CEP290

Inheritance

Autosomal recessive

Signs and symptoms

Affected cats typically have normal vision at birth, but develop early funduscopic changes at the age of 1.5–2 years. rdAc eventually results in blindness. In most cases, the disease will manifest as night blindness or nervousness in unfamiliar environments. Even when completely blind, many cats may appear to "see" normally as they have memorized the layout of their environment during their life.

How is it diagnosed

rdAc is diagnosed with an in-depth opthalmic exam. Your veterinarian can both diagnose and stage the disease using this tool.

Breeds at higher risk

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Citations

https://pubmed.ncbi.nlm.nih.gov/17507457/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.