Disease overview

Congenital myasthenic syndrome, also known as CMS or muscular dystrophy, is a heriditary disorder most commonly seen in the Devon Rex and Sphynx breeds. It is caused by a deficiency of the acetylcholinesterase enzyme (AChE). This disease is characterized by weakness, especially following exertion, stress or excitement. Cats suffering from CMS generally die of asphyxiation due to choking on food or aspiration pneumonia by two years of age.

Gene name

COLQ

Inheritance

Autosomal recessive

Signs and symptoms

Cats with CMS present with generalized weakness, often following exercise. A common presentation is resting front limbs on a nearby object while sitting in a "chipmunk" pose. This disease is typically progressive, but, in some cases, can be stable.

How is it diagnosed

Diagnosis can be made as early as 3 weeks old and often depends upon the previously discussed signs. Once suspected, a genetic test can be performed to diagnose the condition definitively.

Breeds at higher risk

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Citations

https://pubmed.ncbi.nlm.nih.gov/26374066/ https://pubmed.ncbi.nlm.nih.gov/26327126/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.