Disease overview

Fibrodysplasia ossificans is a rare genetic disease that results in the ossification (turning to bone) of skeletal muscle-associated connective tissue. The disease results in the gradual bone formation outside the skeleton, which leads to progressively restricted movement.

Gene name

ACVR1

Inheritance

Autosomal dominant

Signs and symptoms

Cinical signs of this disease include hard muscles, usually starting in the limbs, a stiff walk and reluctance to move. This condition is progressive and fatal.

How is it diagnosed

A diagnosis of this disease is made based on clinical signs and history. It is confirmed with biopsy and histology of the affected muscles.

Breeds at higher risk

Current data does not indicate that specific breeds are at a higher risk.

Citations

https://pubmed.ncbi.nlm.nih.gov/1484375/ https://pubmed.ncbi.nlm.nih.gov/31007133/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.