Disease overview

Polycystic Kidney Disease is an inherited condition which causes fluid-filled structures, called cysts, to develop on the kidneys. This adult-onset disease leads to kidney enlargement and decreased functionality of the organ.

Gene name

PKD1

Inheritance

Autosomal dominant

Signs and symptoms

Signs of kidney dysfunction include increased water intake, increased to excessive urination, vomiting, lethargy, and abdominal pain. This is an adult-onset disease.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Laboratory tests and an abdominal ultrasound may help with diagnosis. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Gharahkhani P, O'Leary CA, Kyaw-Tanner M, Sturm RA, Duffy DL. A non-synonymous mutation in the canine Pkd1 gene is associated with autosomal dominant polycystic kidney disease in Bull Terriers. PLoS One. 2011;6(7):e22455. doi: 10.1371/journal.pone.0022455. Epub 2011 Jul 27. PMID: 21818326; PMCID: PMC3144903.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.