Disease overview

Primary hyperoxaluria type II, otherwise known as oxalosis II, is a genetic disease characterized by the overproduction of a substance called oxalate (also known as oxalic acid). Oxalate can combine with calcium to form calcium oxalate in the kidneys, eventually leading to kidney stones. Deposits of calcium oxalate can result in kidney damage, kidney failure, and injury to other organs. This disease is caused by a deficiency in the glyoxylate reductase/hydroxypyruvate reductase (GRHPR) enzyme, which is typically responsible for preventing the buildup of oxalate.

Gene name

GRHPR

Inheritance

Autosomal recessive

Signs and symptoms

The most common clinical sign of this disease is AKI (acute kidney injury) that develops as early as 5-9 months old. Affected cats are also very weak and lethargic.

How is it diagnosed

Diagnosis of oxalosis II is done via histology of the liver and examination of the enzyme activity.

Breeds at higher risk

Current data does not indicate that specific breeds are at a higher risk.

Citations

https://academic.oup.com/jhered/article/100/suppl_1/S2/896719

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.