Disease overview

Vitamin D deficiency, also known as rickets, is characterized by the softening of the bones and an increased rate of bone deformities and fractures.

Gene name

CYP27B1 (associated with Type 1A), CYP2R1 (associated with Type 1B)

Inheritance

Likely autosomal recessive

Signs and symptoms

Cats with rickets often have bone deformities and a history of frequent fractures and slow growth. They present with lethargy, and generalized pain symptoms. Clinically, these cats often have hypocalcemia, hyperphosphatemia, increased alkaline phosphatase and creatine kinase, eosinophilia, and hyperparathyroidism.

How is it diagnosed

Diagnosis of rickets is multifactorial and many other causes must be ruled out before the genetic cause is considered. A detailed history and examination are key. Bloodwork results and radiographs are often essential as well.

Breeds at higher risk

Current data does not indicate that specific breeds are at a higher risk.

Citations

https://pubmed.ncbi.nlm.nih.gov/19138382/ https://pubmed.ncbi.nlm.nih.gov/30777056/ https://pubmed.ncbi.nlm.nih.gov/22553308/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.