Disease overview

Dwarfism due to Growth Hormone (GH) deficiency is a condition that leads to growth abnormalities. Growth hormones stimulate growth, cell reproduction, and cell regeneration.

Gene name

GH1

Inheritance

Autosomal recessive

Signs and symptoms

Clinical signs of development abnormalities present at around 6 months of age. These include disproportionate dwarfism, retained deciduous (baby) teeth, and retained puppy coat. Puppies can present with hypoglycemia.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Definitive diagnosis of this condition will require a Growth Hormone test. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Iio A, Maeda S, Yonezawa T, Momoi Y, Motegi T. Isolated growth hormone deficiency in a Chihuahua with a GH1 mutation. J Vet Diagn Invest. 2020 Sep;32(5):733-736. doi: 10.1177/1040638720938671. Epub 2020 Jul 9. PMID: 32646299; PMCID: PMC7488967.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.