Disease overview

Colorectal hamartomatous polyposis and ganglioneuromatosis, also known as Cowden Syndrome, is an inherited gastrointestinal disease that leads to the thickening of colon and rectal tissues. This disease is characterized by an overgrowth of mature colorectal cells and tissues, as well as of the ganglion nerve cells in these same regions.

Gene name

PTEN

Inheritance

Autosomal dominant

Signs and symptoms

Clinical signs include rectal bleeding, straining to defecate, and rectal prolapse.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Tissue biopsies may be indicated. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Bemelmans I, Küry S, Albaric O, Hordeaux J, Bertrand L, Nguyen F, Abadie J. Colorectal hamartomatous polyposis and ganglioneuromatosis in a dog. Vet Pathol. 2011 Sep;48(5):1012-5. doi: 10.1177/0300985810384411. Epub 2010 Oct 15. PMID: 20952721.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.