Disease overview

Intestinal lipid malabsorption is caused by a genetic mutation found in the Australian Kelpie. This disease causes a lack of fat absorption, leading to stunted growth and other abnormalities soon after birth.

Gene name

ACSL5

Inheritance

Autosomal recessive

Signs and symptoms

Dogs affected by this disease may exhibit stunted growth after birth. Changes in feces will occur, including yellowish, loose stool as well as increased volume and occurrence. In addition increased food consumption, abdominal distension, and a wiry coat may be present.

How is it diagnosed

A veterinarian will review health history, conduct a thorough exam, and note any clinical signs. Genetic testing can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

O'Brien MJ, Beijerink NJ, Sansom M, Thornton SW, Chew T, Wade CM. A large deletion on CFA28 omitting ACSL5 gene is associated with intestinal lipid malabsorption in the Australian Kelpie dog breed. Sci Rep. 2020 Oct 26;10(1):18223. doi: 10.1038/s41598-020-75243-x. PMID: 33106515; PMCID: PMC7589484.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.