Disease overview

Muscular dystrophy is a group of degenerative muscle disorders that are characterized by progressive muscle dysfunction. Limb-girdle muscular dystrophy, Type R3, presents with general muscle weakness.

Gene name

SGCA

Inheritance

Autosomal recessive

Signs and symptoms

Affected dogs will show signs of general muscle weakness which may include a stiff gait, exercise intolerance, and swallowing difficulties.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Urine tests may show products related to the breakdown of muscle. Muscle biopsy may be indicated for a definitive diagnosis. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Miniature Dachshund

Citations

Mickelson JR, Minor KM, Guo LT, Friedenberg SG, Cullen JN, Ciavarella A, Hambrook LE, Brenner KM, Helmond SE, Marks SL, Shelton GD. Sarcoglycan A mutation in miniature dachshund dogs causes limb-girdle muscular dystrophy 2D. Skelet Muscle. 2021 Jan 7;11(1):2. doi: 10.1186/s13395-020-00257-y. PMID: 33407862; PMCID: PMC7789357.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.