Disease overview

Chondrodysplasia is a bone disease characterized by defective cartilage development. It can lead to abnormal development of the joints and growth plates in the bone, causing skeletal development issues.

Gene name

ITGA10

Inheritance

Autosomal recessive

Signs and symptoms

Affected dogs will have disproportional body sizes, with short legs and normal sized body. This disease can present with curved limbs.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Radiographs may be indicated to show abnormal bone development. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

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Citations

Kyöstilä K, Lappalainen AK, Lohi H. Canine chondrodysplasia caused by a truncating mutation in collagen-binding integrin alpha subunit 10. PLoS One. 2013 Sep 25;8(9):e75621. doi: 10.1371/journal.pone.0075621. PMID: 24086591; PMCID: PMC3783422.

Bingel SA, Sande RD. Chondrodysplasia in the Norwegian Elkhound. Am J Pathol. 1982 May;107(2):219-29. PMID: 7081383; PMCID: PMC1916011.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.