Disease overview

Osteochondromatosis is a musculoskeletal and connective tissue disease. It is a benign condition that involves the synovial membranes in joints. Cartilage overdevelops in these spaces, leading to joint damage and discomfort.

Gene name

EXT2

Inheritance

Autosomal dominant

Signs and symptoms

Clinical signs include swelling, tenderness, creaking or grinding, and/or joints with a limited range of motion.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Radiographs of joints help with a definitive diagnosis. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Friedenberg SG, Vansteenkiste D, Yost O, Treeful AE, Meurs KM, Tokarz DA, Olby NJ. A de novo mutation in the EXT2 gene associated with osteochondromatosis in a litter of American Staffordshire Terriers. J Vet Intern Med. 2018 May;32(3):986-992. doi: 10.1111/jvim.15073. Epub 2018 Feb 27. PMID: 29485212; PMCID: PMC5980316.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.