Acral Mutilation Syndrome is a brain and spinal cord condition characterized by an inability to feel pain.
GDNF
Autosomal recessive
Clinical signs appear in young puppies who exhibit an inability to feel pain in distal parts of the body, including the feet. This may present as self-mutilation, as well as excessive licking, biting, and chewing of the feet.
A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.
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Plassais J, Lagoutte L, Correard S, Paradis M, GuaguÚre E, Hédan B, Pommier A, Botherel N, Cadiergues MC, Pilorge P, Silversides D, Bizot M, Samuels M, Arnan C, Johnson R, Hitte C, Salbert G, Méreau A, Quignon P, Derrien T, André C. A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies. PLoS Genet. 2016 Dec 29;12(12):e1006482. doi: 10.1371/journal.pgen.1006482. PMID: 28033318; PMCID: PMC5198995.
Correard, S., Plassais, J., Lagoutte, L., Paradis, M., GuagÚre, E., Quignon, P., Derrien, T., André, C. A spontaneous dog model for a human sensory neuropathy: identification of a mutation in the upstream region of a neurotrophic factor. Bull Acad Vét Fr 169:190-194, 2017. DOI: 10.4267/2042/61953.
Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.
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