Disease overview

Canine generalized myoclonic epilepsy with photosensitivity is an early-onset neurological disease that affects young Rhodesian Ridgeback dogs. It is characterized by seizures with distinct jerking motions and uncontrolled muscle movements, that can occur in response to bright light.

Gene name

DIRAS1

Inheritance

Autosomal recessive

Signs and symptoms

Seizures often involve the front half of the body during a relaxed or drowsy state. Affected dogs may appear normal between episodes, and then confused or scared following an episode.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Neurological tests, including imaging, may be required for a definitive diagnosis. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Wielaender F, Sarviaho R, James F, Hytönen MK, Cortez MA, Kluger G, Koskinen LL, Arumilli M, Kornberg M, Bathen-Noethen A, Tipold A, Rentmeister K, Bhatti SF, Hülsmeyer V, Boettcher IC, Tästensen C, Flegel T, Dietschi E, Leeb T, Matiasek K, Fischer A, Lohi H. Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2669-2674. doi: 10.1073/pnas.1614478114. Epub 2017 Feb 21. PMID: 28223533; PMCID: PMC5347561.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.