Disease overview

This disorder of sexual development causes lethality in the embryonic stage. Dogs with this genotype will not develop further and therefore will not be born.

Gene name

BTBD17

Inheritance

Autosomal recessive lethal

Signs and symptoms

There are no clinical signs associated with this disease.

How is it diagnosed

Diagnosis can be based on genetic testing.

Breeds at higher risk

Citations

Meyers-Wallen VN, Boyko AR, Danko CG, Grenier JK, Mezey JG, Hayward JJ, Shannon LM, Gao C, Shafquat A, Rice EJ, Pujar S, Eggers S, Ohnesorg T, Sinclair AH. XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris). PLoS One. 2017 Oct 20;12(10):e0186331. doi: 10.1371/journal.pone.0186331. PMID: 29053721; PMCID: PMC5650465.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.