Disease overview

Hyperkeratosis is a skin maturation disorder characterized by the thickening and hardening of an affected dog's footpads, nose, and snout. This condition leads to discomfort and cracking of the affected areas as early as 8 weeks of age.

Gene name

KRT10

Inheritance

Autosomal recessive

Signs and symptoms

Clinical signs include large, greasy flakes of dandruff, as well as thickened and hardened areas. This can lead to severe discomfort and pain with cracking. This condition does not cause itchiness.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. A skin biopsy can help with diagnosis. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Credille KM, Barnhart KF, Minor JS, Dunstan RW. Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs. Br J Dermatol. 2005 Jul;153(1):51-8. doi: 10.1111/j.1365-2133.2005.06735.x. PMID: 16029326.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.