Disease overview

Ectodermal dysplasia is characterized by hairlessness and changes in tooth shape.

Gene name

FOXI3

Inheritance

Autosomal incomplete dominance

Signs and symptoms

Affected dogs exhibit varying degrees of hairlessness across the entire body, as well as abnormal or missing teeth.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

, , P

Citations

Drögemüller C, Karlsson EK, Hytönen MK, Perloski M, Dolf G, Sainio K, Lohi H, Lindblad-Toh K, Leeb T. A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science. 2008 Sep 12;321(5895):1462. doi: 10.1126/science.1162525. PMID: 18787161.

Kimura T, Ohshima S, Doi K. The inheritance and breeding results of hairless descendants of Mexican hairless dogs. Lab Anim. 1993 Jan;27(1):55-8. doi: 10.1258/002367793781082403. PMID: 8437436.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.