Disease overview

Darier Disease is a skin condition characterized by loss of cell-to-cell adhesion and abnormal keratinization that results in hairless, plaque-like lesions on the skin.

Gene name

ATP2A2

Inheritance

Autosomal dominant

Signs and symptoms

Dogs affected with Darier Disease often have crusted lesions, with possible ulceration. Ears are a common site for these lesions.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Histology of the lesion will show acantholytic cells. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Linek M, Doelle M, Leeb T, Bauer A, Leuthard F, Henkel J, Bannasch D, Jagannathan V, Welle MM. ATP2A2 SINE Insertion in an Irish Terrier with Darier Disease and Associated Infundibular Cyst Formation. Genes (Basel). 2020 Apr 28;11(5):481. doi: 10.3390/genes11050481. PMID: 32354065; PMCID: PMC7291265.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.