Disease overview

Ichthyosis is a primary skin condition characterized by flaky, cracked, and scaling skin. This occurs because of improper keratinization of the outermost layer of the skin, called the epidermis, and can lead to other systemic illness. Scales can become progressively darker leading to thick gray or black sections that flake off. Larger, thicker scales can lead to discomfort, though this condition does not present with itchiness. Secondary skin infections and other systemic illness may occur.

Gene name

SLC27A4

Inheritance

Autosomal recessive

Signs and symptoms

The skin is rough and thick, with greasy flakes may stick to the hair. There may be thickening of footpads or thickened and pigmented regions of the body. The skin around the eyes and nose are typically affected. This disease typically worsens with age and secondary skin infections and other systemic illness may occur.

How is it diagnosed

Clinical signs are suggestive, as other conditions may present with similar signs as ichthyosis. A skin biopsy can provide a definitive diagnosis. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Metzger J, Wöhlke A, Mischke R, Hoffmann A, Hewicker-Trautwein M, Küch EM, Naim HY, Distl O. A Novel SLC27A4 Splice Acceptor Site Mutation in Great Danes with Ichthyosis. PLoS One. 2015 Oct 27;10(10):e0141514. doi: 10.1371/journal.pone.0141514. PMID: 26506231; PMCID: PMC4624637.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.