Junctionalis Epidermolysis Bullosa is skin and connective tissue condition that is characterized by a separation of the specific layers of the skin. Affected dogs will have extremely stretchy skin that is easily injured because it is detached from the underlying tissues.
LAMA3
Autosomal recessive
Affected dogs will have extremely stretchy skin that is easily injured because it is detached from the underlying tissues. They may present with blisters, especially around the mouth and limbs, as well as signs of severe respiratory distress.
A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. A skin biopsy can help with diagnosis. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.
,
Capt A, Spirito F, Guaguere E, Spadafora A, Ortonne JP, Meneguzzi G. Inherited junctional epidermolysis bullosa in the German Pointer: establishment of a large animal model. J Invest Dermatol. 2005 Mar;124(3):530-5. doi: 10.1111/j.0022-202X.2004.23584.x. PMID: 15737193.
Herrmann I, Linder KE, Meurs KM, Friedenberg SG, Cullen J, Olby N, Bizikova P. Canine junctional epidermolysis bullosa due to a novel mutation in LAMA3 with severe upper respiratory involvement. Vet Dermatol. 2021 Aug;32(4):379-e108. doi: 10.1111/vde.12972. PMID: 34250689; PMCID: PMC8279226.
Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.
Recommended by top vets with decades of experience
21 breeds
64 genetic health markersÂ
50 genetic trait markersÂ