Disease overview

Pituitary Dwarfism is a rare inherited endocrine disorder characterized by growth hormone deficiency. The pituitary glands fail to develop normally, which creates a deficiency in hormones associated with growth and development. Affected dogs never reach normal adult size and typically retain their puppy coat.

Gene name

POU1F1

Inheritance

Autosomal recessive

Signs and symptoms

Affected dogs will appear normal as puppies, but with slower growth rates. Retention of puppy coat is evident around 2 months of age. The dog may present with a shrill bark, areas of baldness, and lack or delayed permanent dentition.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Genetic testing assists veterinarians with diagnosis and helps breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Kyöstilä K, Niskanen JE, Arumilli M, Donner J, Hytönen MK, Lohi H. Intronic variant in POU1F1 associated with canine pituitary dwarfism. Hum Genet. 2021 Nov;140(11):1553-1562. doi: 10.1007/s00439-021-02259-2. Epub 2021 Feb 6. PMID: 33550451; PMCID: PMC8519942.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.