Disease overview

Leukocytes, also known as white blood cells, are an essential part of the immune system when fighting infections and injury. Leukocyte adhesion deficiency, Type III, is a rare disorder that causes a failed response of platelets and white blood cells, leading to higher susceptibility of infections and bleeding.

Gene name

FERMT3

Inheritance

Autosomal recessive

Signs and symptoms

Affected dogs will show signs of increased infection risk, as well as an increase in bleeding. They may have recurrent skin infections, lameness, and/or swollen, bleeding gums.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. This disease is typically diagnosed in puppies and young adults. Laboratory testing can assess leukocyte counts and clotting times. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Boudreaux MK, Wardrop KJ, Kiklevich V, Felsburg P, Snekvik K. A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost. 2010 Feb;103(2):475-7. doi: 10.1160/TH09-09-0571. Epub 2009 Nov 13. PMID: 20126836.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.