Myeloperoxidase deficiency is an inherited disorder that is characterized by decreased or completely absent myeloperoxidase activity in neutrophils and monocytes. Myeloperoxidase is a component of the immune system, as it forms reactive oxygen species as part of the immune response to pathogens. In humans, it has been associated with increased susceptibility to certain fungal infections, such as from Candida albicans.
MPO
Autosomal recessive
There are no clinical signs associated with this disease.
A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Laboratory tests that assess complete blood count (CBC) can help support a diagnosis, but genetic testing is the most definitive way to discover if a dog has mutations in the MPO gene that are responsible for this condition.
Italian hound
Gentilini F, Zambon E, Mancini D, Turba ME. A nonsense mutation in the myeloperoxidase gene is responsible for hereditary myeloperoxidase deficiency in an Italian hound dog. Anim Genet. 2016 Oct;47(5):632-3. doi: 10.1111/age.12463. Epub 2016 Jun 14. PMID: 27296514.
Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.
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