Hypomyelination is an inherited nervous system disease that causes defective neuronal axons. Myelin is crucial for relaying information across great distances on nerves. Defective neurons create a delay of information relay between the brain and the body.
FNIP2
Autosomal recessive
Early-onset symptoms present in puppyhood. These may include tremors, weak muscles, and loss of limb control.
A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Neurological tests, including imaging, may be required for a definitive diagnosis. Genetic testing is necessary to determine an underlying genetic cause.
Pemberton TJ, Choi S, Mayer JA, Li FY, Gokey N, Svaren J, Safra N, Bannasch DL, Sullivan K, Breuhaus B, Patel PI, Duncan ID. A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination. Glia. 2014 Jan;62(1):39-51. doi: 10.1002/glia.22582. PMID: 24272703; PMCID: PMC4026025.
MillĂĄn Y, Mascort J, Blanco A, Costa C, Masian D, Guil-Luna S, Pumarola M, Martin de Las Mulas J. Hypomyelination in three Weimaraner dogs. J Small Anim Pract. 2010 Nov;51(11):594-8. doi: 10.1111/j.1748-5827.2010.00997.x. PMID: 20973788.
Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.
Recommended by top vets with decades of experience
21 breeds
64 genetic health markersÂ
50 genetic trait markersÂ