Disease overview

Polyneuropathy, NDRG1-related, is an early-onset progressive polyneuropathy. Polyneuropathy is characterized by the degeneration of the nerves in the body, primarily in the hind limbs and larynx.

Gene name

NDRG1

Inheritance

Autosomal recessive

Signs and symptoms

Clinical signs of this disease include weakness of the hind limbs, exercise intolerance, muscle atrophy, and loud respiration or difficulty breathing due to laryngeal paralysis. Signs develop from 7 to 18 months of age.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Neurological tests, including imaging, may be required for a definitive diagnosis. Genetic testing is necessary to determine an underlying genetic cause.

Breeds at higher risk

,

Citations

Joyce H, Burmeister LM, Wright H, Fleming L, Oliver JAC, Mellersh C. Identification of a variant in NDP associated with X-linked retinal dysplasia in the English cocker spaniel dog. PLoS One. 2021 May 4;16(5):e0251071. doi: 10.1371/journal.pone.0251071. Erratum in: PLoS One. 2022 Jul 28;17(7):e0272477. PMID: 33945575; PMCID: PMC8096109.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.