Disease overview

Primary open angle glaucoma (POAG) is a condition that causes pressure to build up in the eye as a result of a genetic mutation. The increased pressure of glaucoma leads to eye pain and vision loss. The genetic defect that causes POAG prevents the normal release of fluids in a dog's eyes, and as intraocular pressure increases, it can lead to retinal ganglia cell death. These nerve cells receive visual information from the retina and transfer it through the optic nerve to the brain.

Gene name

ADAMTS10

Inheritance

Autosomal recessive

Signs and symptoms

Symptoms of POAG typically occur between 8-18 months of age. Signs may appear suddenly and dramatically. The affected eye may have dilated pupils and enlarged vessels. An affected dog may present with aversion to bright light, head shaking, or pawing of the eyes.

How is it diagnosed

A thorough veterinary ophthalmic exam can be performed to measure the intraocular pressure of the eye. Genetic testing assists veterinarians with diagnosis and helps breeders identify affected and carrier dogs.

Breeds at higher risk

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Citations

Kuchtey J, Olson LM, Rinkoski T, Mackay EO, Iverson TM, Gelatt KN, Haines JL, Kuchtey RW. Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet. 2011 Feb;7(2):e1001306. doi: 10.1371/journal.pgen.1001306. Epub 2011 Feb 17. PMID: 21379321; PMCID: PMC3040645.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.