Progressive Retinal Atrophy (PRA) causes breakdown of the retina, which is a part of the eye essential for vision. This is a progressive, non-painful disease that affects both types of photoreceptors: rods and cones. Rods are essential for night vision and movement, while cones are used for day vision and color.
IFT122
Autosomal recessive
PRA is a slowly progressive disease that causes vision loss in both eyes. This provides more opportunities for helping an affected dog adapt to its changing visual environment. This disease has a varying onset of age ranging from one year into adulthood. Signs typically start with night blindness, which progresses to daytime vision loss.
Thorough examination of the eyes and clinical signs. A veterinary ophthalmologic exam can determine if there are changes in the eye that have or will lead to vision loss. Genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.
Finnish Lapphund,
Kaukonen M, Pettinen IT, Wickström K, Arumilli M, Donner J, Juhola IJ, Holopainen S, Turunen JA, Yoshihara M, Kere J, Lohi H. A missense variant in IFT122 associated with a canine model of retinitis pigmentosa. Hum Genet. 2021 Nov;140(11):1569-1579. doi: 10.1007/s00439-021-02266-3. Epub 2021 Feb 19. PMID: 33606121; PMCID: PMC8519925.
Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.
Recommended by top vets with decades of experience
21 breeds
64 genetic health markersÂ
50 genetic trait markersÂ