Disease overview

Leukencephalomyelopathy is a neurodegenerative disorder that affects the white matter of the central nervous system (CNS). White matter is crucial for relaying information from one place to another.

Gene name

NAPEPLD

Inheritance

Autosomal recessive

Signs and symptoms

Juvenile-onset clinical signs include abnormal, uncoordinated movements (ataxia). This disease is severe and typically leads to immobility within a few months.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Neurological tests, including imaging, may be required for a definitive diagnosis. Genetic testing is necessary to determine an underlying genetic cause.

Breeds at higher risk

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Citations

Minor KM, Letko A, Becker D, Drögemüller M, Mandigers PJJ, Bellekom SR, Leegwater PAJ, Stassen QEM, Putschbach K, Fischer A, Flegel T, Matiasek K, Ekenstedt KJ, Furrow E, Patterson EE, Platt SR, Kelly PA, Cassidy JP, Shelton GD, Lucot K, Bannasch DL, Martineau H, Muir CF, Priestnall SL, Henke D, Oevermann A, Jagannathan V, Mickelson JR, Drögemüller C. Canine NAPEPLD-associated models of human myelin disorders. Sci Rep. 2018 Apr 11;8(1):5818. doi: 10.1038/s41598-018-23938-7. PMID: 29643404; PMCID: PMC5895582.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.