Disease overview

Epidermolysis bullosa (EB) is a genetic disease caused by mutations in the genes coding for structural proteins of the basal keratinocytes' cytoskeleton or the basement membrane zone. The effect of such mutations is manifested in thin and fragile skin and mucous membranes. EB can be classified in three categories, depending on the ultrastructural levels of tissue separation: epidermolysis bullosa simplex, junctional epidermolysis bullosa and dystrophic epidermolysis bullosa. In cats, EB simplex is characterized by split formation within the basal cell layer of the epidermis and oral mucous epithelium, based on case study reports.

Gene name

KRT14

Inheritance

Likely autosomal recessive

Signs and symptoms

The clinical signs of this disease include fragile skin, as well as ulcers in the mouth and gums. Cats can also have abnormal claws and sloughed paw pads.

How is it diagnosed

Detailed history, clinical signs, and histopathology of the skin and affected regions are necessary components of the diagnostic process.

Breeds at higher risk

Current data does not indicate that specific breeds are at a higher risk.

Citations

https://pubmed.ncbi.nlm.nih.gov/25354580/ https://pubmed.ncbi.nlm.nih.gov/15725108/ https://pubmed.ncbi.nlm.nih.gov/32657488/

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.