Disease overview

Epidermolysis Bullosa Simplex (EBS) is skin and connective tissue condition. It is due to deficiency in the protein called plectin, which binds layers of the skin together. Without this protein, blisters form between the layers of the skin.

Gene name

PLEC

Inheritance

Autosomal recessive

Signs and symptoms

Affected dogs will present with failure to thrive. Other signs include ulcers on the lips, tongue, nose, paw pads, and abdomen.

How is it diagnosed

A veterinarian will review health history, conduct a thorough exam, and note any clinical signs. A skin biopsy can help with a definitive diagnosis. Genetic testing assists veterinarians with diagnosis and helps breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Mauldin EA, Wang P, Olivry T, Henthorn PS, Casal ML. Epidermolysis bullosa simplex in sibling Eurasier dogs is caused by a PLEC non-sense variant. Vet Dermatol. 2017 Feb;28(1):10-e3. doi: 10.1111/vde.12394. Epub 2016 Nov 7. PMID: 27878870; PMCID: PMC5324056.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.