Disease overview

Pituitary Dwarfism is a rare inherited endocrine disorder characterized by growth hormone deficiency. The pituitary glands fail to develop normally, which creates a deficiency in hormones associated with growth and development. Affected dogs never reach normal adult size and typically retain their puppy coat.

Gene name

LHX3

Inheritance

Autosomal recessive

Signs and symptoms

Affected dogs will appear normal as puppies, but with slower growth rates. Retention of puppy coat is evident around 2 months of age. The dog may present with a shrill bark, areas of baldness, and lack or delayed permanent dentition.

How is it diagnosed

A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Genetic testing assists veterinarians with diagnosis and helps breeders identify affected and carrier dogs.

Breeds at higher risk

Citations

Voorbij AM, van Steenbeek FG, Vos-Loohuis M, Martens EE, Hanson-Nilsson JM, van Oost BA, Kooistra HS, Leegwater PA. A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs. PLoS One. 2011;6(11):e27940. doi: 10.1371/journal.pone.0027940. Epub 2011 Nov 23. PMID: 22132174; PMCID: PMC3223203.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.