Disease overview

Glucocorticoid resistance in dogs is characterized by a less reactive glucocorticoid receptor. Glucocorticoids are very common medications that are used in the veterinary field. Decreased sensitivity to these drugs may have adverse side effects and warrant changes in treatment plans.

Gene name

NR3C1

Inheritance

Unknown

Signs and symptoms

The administration of glucocorticoid medication can prompt clinical signs such as excessive thirst, increased urination, abdominal distension, loss of hair, and/or skin lesions in glucocorticoid resistant dogs.

How is it diagnosed

A veterinarian will take a proper history and perform a physical exam. Blood test may help diagnose this condition. Genetic and laboratory testing can be used to diagnose the condition.

Breeds at higher risk

N/A

Citations

Yamanaka K, Okuda M, Mizuno T. Functional characterization of canine wild type glucocorticoid receptor and an insertional mutation in a dog. BMC Vet Res. 2019 Oct 24;15(1):363. doi: 10.1186/s12917-019-2129-9. PMID: 31651346; PMCID: PMC6813069.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.