Disease overview

Bernard-Soulier syndrome, Type C, is a rare bleeding disorder found in Cocker Spaniels. This disease is characterized by a defective platelet membrane receptor, which leads to failure of platelet plug stabilization during the coagulation/clotting pathway.

Gene name

GP9

Inheritance

Autosomal recessive

Signs and symptoms

Affected dogs can present with mucosal bleeding, nose bleeding, digested blood in the stool, and blood in the urine. Clotting conditions are typically recognized during trauma or in preparation for surgery.

How is it diagnosed

Hemostatic diseases are diagnosed with multiple blood tests that evaluate clotting times and platelet morphology.

Breeds at higher risk

Citations

Gentilini F, Turba ME, Giancola F, Chiocchetti R, Bernardini C, Dajbychova M, Jagannathan V, Drögemüller M, Drögemüller C. A large deletion in the GP9 gene in Cocker Spaniel dogs with Bernard-Soulier syndrome. PLoS One. 2019 Sep 4;14(9):e0220625. doi: 10.1371/journal.pone.0220625. PMID: 31484196; PMCID: PMC6726462.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.