Disease overview

Platelets are essential to the coagulation process. Platelet Factor X Receptor Deficiency, also known as Canine Scott Syndrome (CSS), is an inherited disease characterized by platelet dysfunction. As a result, the normal process of blood clotting is compromised. Factor X is used specifically in secondary hemostasis, which is the process used to stabilize a clot after injury or trauma.

Gene name

ANO6

Inheritance

Autosomal recessive

Signs and symptoms

Clinical signs associated with CSS and delayed clotting of the blood include excessive bruising, spontaneous and/or excessive bleeding following injury or surgery, non-surgical bleeds such as nosebleeds (which can be recurrent), and/or non-traumatic hemorrhage into the joints and soft tissues.

How is it diagnosed

A veterinarian will take a look at clinical signs and perform laboratory testing. As there are many factors that take part in the coagulation process, genetic testing can be used to determine if the cause is genetic.

Breeds at higher risk

Citations

Brooks MB, Catalfamo JL, MacNguyen R, Tim D, Fancher S, McCardle JA. A TMEM16F point mutation causes an absence of canine platelet TMEM16F and ineffective activation and death-induced phospholipid scrambling. J Thromb Haemost. 2015 Dec;13(12):2240-52. doi: 10.1111/jth.13157. Epub 2015 Nov 20. PMID: 26414452. Brooks M, Etter K, Catalfamo J, Brisbin A, Bustamante C, Mezey J. A genome-wide linkage scan in German shepherd dogs localizes canine platelet procoagulant deficiency (Scott syndrome) to canine chromosome 27. Gene. 2010 Jan 15;450(1-2):70-5. doi: 10.1016/j.gene.2009.09.016. PMID: 19854246; PMCID: PMC3064881.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.