P2Y12 Receptor Platelet Disorder is a blood clotting condition characterized by platelet dysfunction. Platelets are crucial in the coagulation pathways for clotting of the blood. When tissue is damaged, platelet aggregation and plug formation does not occur. This leads to excessive bleeding upon injury or surgery.
P2RY12
Autosomal recessive
Affected dogs will present with excessive bleeding during trauma or surgery. However, this disease does not cause spontaneous bleeding.
A veterinarian will conduct a thorough exam, including a review of health history and any clinical signs. Blood tests that evaluate clotting times and platelet morphology will likely be indicated. There are many factors involved in the coagulation cascade, so genetic testing is necessary to determine if there is an underlying genetic cause, which can assist veterinarians with diagnosis and help breeders identify affected and carrier dogs.
Boudreaux MK, Martin M. P2Y12 receptor gene mutation associated with postoperative hemorrhage in a Greater Swiss Mountain dog. Vet Clin Pathol. 2011 Jun;40(2):202-6. doi: 10.1111/j.1939-165X.2011.00318.x. Epub 2011 May 9. PMID: 21554368.
Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.
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