Factor VII deficiency is a secondary hemostatic disease that leads to failure of platelet plug stabilization during the coagulation/clotting pathway.
F7
Autosomal recessive
Factor VII deficiency can present with mild bleeding. Clotting conditions are typically recognized during trauma or preparation for surgery.
Secondary hemostatic diseases are diagnosed with a range of blood tests that determine blood clotting times.
, Alaskan Sled Dog, ,
Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost. 2006 Dec;4(12):2616-22. doi: 10.1111/j.1538-7836.2006.02203.x. Epub 2006 Sep 8. PMID: 16961583.
Thorsrud JA, Huson HJ. Description of breed ancestry and genetic health traits in arctic sled dog breeds. Canine Med Genet. 2021 Sep 20;8(1):8. doi: 10.1186/s40575-021-00108-z. PMID: 34544496; PMCID: PMC8454093.
Kaae JA, Callan MB, Brooks MB. Hereditary factor VII deficiency in the Alaskan Klee Kai dog. J Vet Intern Med. 2007 Sep-Oct;21(5):976-81. doi: 10.1892/0891-6640(2007)21[976:hfvdit]2.0.co;2. PMID: 17939552.
Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.
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