Factor VII deficiency

Disease overview

Factor VII deficiency is a secondary hemostatic disease that leads to failure of platelet plug stabilization during the coagulation/clotting pathway.

Gene name

F7

Inheritance

Autosomal recessive

Signs and symptoms

Factor VII deficiency can present with mild bleeding. Clotting conditions are typically recognized during trauma or preparation for surgery.

How is it diagnosed

Secondary hemostatic diseases are diagnosed with a range of blood tests that determine blood clotting times.

Breeds at higher risk

Alaskan Klee Kai, Alaskan Sled Dog, Beagle, Scottish Deerhound

Citations

Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost. 2006 Dec;4(12):2616-22. doi: 10.1111/j.1538-7836.2006.02203.x. Epub 2006 Sep 8. PMID: 16961583.

Thorsrud JA, Huson HJ. Description of breed ancestry and genetic health traits in arctic sled dog breeds. Canine Med Genet. 2021 Sep 20;8(1):8. doi: 10.1186/s40575-021-00108-z. PMID: 34544496; PMCID: PMC8454093.

Kaae JA, Callan MB, Brooks MB. Hereditary factor VII deficiency in the Alaskan Klee Kai dog. J Vet Intern Med. 2007 Sep-Oct;21(5):976-81. doi: 10.1892/0891-6640(2007)21[976:hfvdit]2.0.co;2. PMID: 17939552.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.