Disease overview

Hemophilia A is a deficiency in Factor VIII (a secondary hemostatic disease), which leads to failure of platelet plug stabilization during the coagulation/clotting pathway.

Gene name

F8

Inheritance

X-Linked recessive

Signs and symptoms

Hemophilia A can cause mild to severe bleeding, with possible spontaneous bleeding depending on the degree of Factor VIII deficiency. Clotting conditions are typically recognized during trauma or preparation for surgery.

How is it diagnosed

Secondary hemostatic diseases are diagnosed with a range of blood tests that determine blood clotting times.

Breeds at higher risk

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Citations

Christopherson PW, Bacek LM, King KB, Boudreaux MK. Two novel missense mutations associated with hemophilia A in a family of Boxers, and a German Shepherd dog. Vet Clin Pathol. 2014 Sep;43(3):312-6. doi: 10.1111/vcp.12172. Epub 2014 Jul 10. PMID: 25040606.

GRAHAM JB, BUCKWALTER JA, et al. Canine hemophilia; observations on the course, the clotting anomaly, and the effect of blood transfusions. J Exp Med. 1949 Aug 1;90(2):97-111. doi: 10.1084/jem.90.2.97. PMID: 18136192; PMCID: PMC2135899.

Giles AR, Tinlin S, Greenwood R. A canine model of hemophilic (factor VIII:C deficiency) bleeding. Blood. 1982 Sep;60(3):727-30. PMID: 6809076.

Kehl A, Haaland AH, Langbein-Detsch I, Mueller E. A SINE Insertion in F8 Gene Leads to Severe Form of Hemophilia A in a Family of Rhodesian Ridgebacks. Genes (Basel). 2021 Jan 21;12(2):134. doi: 10.3390/genes12020134. PMID: 33494213; PMCID: PMC7909816.

Gavazza A, Lubas G, Trotta M, Caldin M. Hemophilia A in a Belgian Shepherd Malinois dog: case report. Res Vet Sci. 2014 Aug;97(1):96-8. doi: 10.1016/j.rvsc.2014.05.007. Epub 2014 May 20. PMID: 24952680.

Mansell PD, Parry BW, Van Orsouw PJ. Haemophilia A in a family of miniature poodles. Aust Vet J. 1990 Nov;67(11):420-1. doi: 10.1111/j.1751-0813.1990.tb03041.x. PMID: 2085303.

Dunning MD, Averis GF, Pattinson H, Targett M, Cade S, Herrtage ME. Haemophilia A (factor VIII deficiency) in a litter of Weimaraners. J Small Anim Pract. 2009 Jul;50(7):357-9. doi: 10.1111/j.1748-5827.2009.00727.x. Epub 2009 Jun 5. PMID: 19508492.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.